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Copper-Catalyzed Aerobic Oxidative Cyclization of Ketoxime Acetates with Pyridines for the Synthesis of Imidazo[1,2-a]pyridines

Zhi-Hui Ren*, Mi-Na Zhao, Yukun Yi, Yao-Yu Wang, Zheng-Hui Guan*

*Key Laboratory of Synthetic and Natural Functional Molecule Chemistry of Ministry of Education, Department of Chemistry & Materials Science, Northwest University, Xi'an 710127, P. R. of China, Email:

Z.-H. Ren, M.-N. Zhao, Y. Yi, Y.-Y. Wang, Z.-H. Guan, Synthesis, 2016, 48, 1920-1926.

DOI: 10.1055/s-0035-1561950

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A copper(I)-catalyzed aerobic oxidative coupling of ketoxime acetates with simple pyridines for the synthesis of imidazo[1,2-a]pyridines tolerates a wide range of functional groups and affords a series of valuable imidazo[1,2-a]pyridines in high yields under mild conditions.

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Key Words

copper, catalysis, pyridines, ketoxime esters, coupling, air, imidazo[1,2-a]pyridines

ID: J66-Y2016