Metal-Free Reduction of Aromatic Nitro Compounds to Aromatic Amines with B₂pin₂ in Isopropanol

Hongtao Lu, Zhiyue Geng, Jingya Li, Dapeng Zou*, Yusheng Wu* and Yangjie Wu*

*Zhengzhou University, Zhengzhou 450052, People's Republic of China; Tetranov International Inc., New Brunswick, New Jersey 08901, United States, Email: zdpzzu.edu.cn, yusheng.wutetranovglobal.com, wyjzzu.edu.cn

H. Lu, Z. Geng, J. Li, D. Zou, Y. Wu, Y. Wu, Org. Lett., 2016, 18, 2774-2776.

DOI: 10.1021/acs.orglett.6b01274

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Abstract

The combination of B₂pin₂ and KOtBu enables a chemoselective, metal-free reduction of aromatic nitro compounds to the corresponding amines in very good yields in isopropanol. The reaction tolerates various reducible functional groups.

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Key Words

Bis(pinacolato)diboron, reduction of nitro compounds

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ID: J54-Y2016