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Synthesis of 3-Substituted Aryl[4,5]isothiazoles through an All-Heteroatom Wittig-Equivalent Process

Fanghui Xu, Yuan Chen, Erkang Fan and Zhihua Sun*

*College of Chemistry and Chemical Engineering, Shanghai University of Engineering Science, 333 Longteng Road, Shanghai 201620, China, Email:

F. Xu, Y. Chen, E. Fan, Z. Sun, Org. Lett., 2016, 18, 2777-2779.

DOI: 10.1021/acs.orglett.6b01338


tert-Butyl sulfoxides can be used as sulfinyl sources in an intramolecular sulfinylation of sulfonamides followed by an all-heteroatom Wittig-equivalent process to afford aryl[4,5]isothiazoles in high yields.

see article for more examples

Acid-Catalyzed Synthesis of Aryl[4,5]isothiazoles through a Sulfenic Acid Pathway

H. Yuan, Z. Sun, Synlett, 2019, 30, 1904-1908.

Key Words

benzisothiazoles, NBS

ID: J54-Y2016