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Fluoroform-Derived CuCF3 for Trifluoromethylation of Terminal and TMS-Protected Alkynes

Lisi He and Gavin Chit Tsui*

*Department of Chemistry, The Chinese University of Hong Kong, Shatin, New Territories, Hong Kong, China, Email:

L. He, G. C. Tsui, Org. Lett., 2016, 18, 2800-2803.

DOI: 10.1021/acs.orglett.6b00999


A fluoroform-derived CuCF3 reagent can be prepared in large quantities and is convenient to use. This reagent, prepared from inexpensive industrial waste fluoroform (CF3H), enables an efficient trifluoromethylation reaction of alkynes in presence of the diamine ligand tetramethylethylenediamine (TMEDA).

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Key Words

trifluoromethylation, oxygen

ID: J54-Y2016