Palladium-Catalyzed Alkoxycarbonylation of Unactivated Secondary Alkyl Bromides at Low Pressure
Brendon T. Sargent and Erik J. Alexanian*
*Department of Chemistry, The University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599, United States, Email: ejaemail.unc.edu
B. T. Sargent, E. J. Alexanian, J. Am. Chem. Soc., 2016, 138, 7520-7523.
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A palladium-catalyzed alkoxycarbonylation of secondary alkyl bromides, that proceeds at low pressure (2 atm CO) under mild conditions, deliver esters from across a diverse range of substrates and represent the first catalytic carbonylations of alkyl bromides with carbon monoxide.
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