Nickel-Catalyzed Reductive Cross-Coupling of Benzyl Chlorides with Aryl Chlorides/Fluorides: A One-Pot Synthesis of Diarylmethanes

Jie Zhang, Gusheng Lu, Jin Xu, Hongmei Sun* and Qi Shen

*The Key Laboratory of Organic Synthesis of Jiangsu Province, College of Chemistry, Chemical Engineering and Materials Science, Soochow University, Suzhou 215123, People's Republic of China, Email: sunhmsuda.edu.cn

J. Zhang, G. Lu, J. Xu, H. Sun, Q. Shen, Org. Lett., 2016, 18, 2860-2863.

DOI: 10.1021/acs.orglett.6b01134

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Abstract

A magnesium-mediated reductive cross-coupling between benzyl chlorides and aryl chlorides or fluorides gives diarylmethanes in good to excellent yields in a one-pot manner using easy-to-access mixed PPh₃/NHC Ni(II) complexes of Ni(PPh₃)(NHC)Br₂ as catalyst precursors.

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Key Words

diarylmethanes, magnesium, nickel

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ID: J54-Y2016