Silver-Catalyzed Three-Component Approach to Quinolines Starting from Anilines, Aldehydes, and Alcohols
Xu Zhang*, Wenmin Liu, Ruixue Sun, Xuefeng Xu, Zhiqiang Wang*, Yanlei Yan
*School of Chemistry and Pharmacony Engineering, Nanyang Normal University, Nanyang 473061, P. R. of China, Email: zhangxuedu126.com
X. Zhang, W. Liu, R. Sun, X. Xu, Z. Wang, Y. Yan, Synlett, 2016, 27, 1563-1568.
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A silver-catalyzed sequential formation of two C-C bonds enabels the construction of a series of polysubstituted quinolines from anilines, aldehydes, and alcohols under mild conditions. The transformation is effective for a broad range of substrates, including aliphatic alcohols, arylalkanols, cycloalkanols, and ethylene glycol.
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multicomponent reactions, silver, catalysis, amines, aldehydes, alcohols, quinolines, air