Organic Chemistry Portal



Silver-Catalyzed Three-Component Approach to Quinolines Starting from Anilines, Aldehydes, and Alcohols

Xu Zhang*, Wenmin Liu, Ruixue Sun, Xuefeng Xu, Zhiqiang Wang*, Yanlei Yan

*School of Chemistry and Pharmacony Engineering, Nanyang Normal University, Nanyang 473061, P. R. of China, Email:

X. Zhang, W. Liu, R. Sun, X. Xu, Z. Wang, Y. Yan, Synlett, 2016, 27, 1563-1568.

DOI: 10.1055/s-0035-1561916

see article for more reactions


A silver-catalyzed sequential formation of two C-C bonds enabels the construction of a series of polysubstituted quinolines from anilines, aldehydes, and alcohols under mild conditions. The transformation is effective for a broad range of substrates, including aliphatic alcohols, arylalkanols, cycloalkanols, and ethylene glycol.

see article for more examples

Key Words

multicomponent reactions, silver, catalysis, amines, aldehydes, alcohols, quinolines, air

ID: J60-Y2016