Divergent Synthesis of Quinazolin-4(3H)-ones and Tryptanthrins Enabled by a tert-Butyl Hydroperoxide/K₃PO₄-Promoted Oxidative Cyclization of Isatins at Room Temperature

Feng-Cheng Jia, Zhi-Wen Zhou, Cheng Xu, Yan-Dong Wu* and An-Xin Wu*

*Key Laboratory of Pesticide & Chemical Biology, Ministry of Education, College of Chemistry, Central China Normal University, Hubei, Wuhan 430079, P. R. China, Email: chwuydmail.ccnu.edu.cn, chwuaxmail.ccnu.edu.cn

F.-C. Jia, Z.-W. Zhou, C. Xu, Y.-D. Wu, A.-X. Wu, Org. Lett., 2016, 18, 2942-2945.

DOI: 10.1021/acs.orglett.6b01291

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Abstract

A synergetic tert-butyl hydroperoxide/K₃PO₄-promoted oxidative cyclization enables a facile synthesis of various functionalized quinazolin-4(3H)-ones from commercially available isatins and amidine hydrochlorides at room temperature.

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Key Words

quinazolinones, tert-butyl hydroperoxide

ID: J54-Y2016

Divergent Synthesis of Quinazolin-4(3H)-ones and Tryptanthrins Enabled by a tert-Butyl Hydroperoxide/K3PO4-Promoted Oxidative Cyclization of Isatins at Room Temperature

Feng-Cheng Jia, Zhi-Wen Zhou, Cheng Xu, Yan-Dong Wu* and An-Xin Wu*

Divergent Synthesis of Quinazolin-4(3H)-ones and Tryptanthrins Enabled by a tert-Butyl Hydroperoxide/K₃PO₄-Promoted Oxidative Cyclization of Isatins at Room Temperature