The synthesis of amino acids by phase-transfer reactions
Martin J. O'Donnell, James M. Boniece, Samuel E. Earp
*Departement of Chemistry, Indiana U.-Purdue U. at Indianapolis (IUPUI), 402 North Blackford Street, Indianapolis IN 46202, USA, Email: modonneliupui.edu
M. J. O'Donnell, J. M. Boniece, S. E. Earp, Tetrahedron Lett., 1978, 19, 2641-2644.
DOI: 10.1016/S0040-4039(01)91563-1 (free Supporting Information)
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The alkylation of a stable Schiff base derived from glycine ethyl ester and benzophenone provides protected amino acids. The reaction is accomplished either by normal anhydrous alkylation or by phase-transfer reagents in a two-phase system.
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