Oxidative Radical Addition-Cyclization of Sulfonyl Hydrazones with Simple Olefins by Binary Acid Catalysis

Xingren Zhong, Jian Lv* and Sanzhong Luo*

*Beijing National Laboratory for Molecular Sciences (BNLMS), Institute of Chemistry, Chinese Academy of Sciences, Beijing, 100190, China, Email: luosziccas.ac.cn, lvjianiccas.ac.cn

X. Zhong, J. Lv, S. Luo, Org. Lett., 2016, 18, 3150-3153.

DOI: 10.1021/acs.orglett.6b01360

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Abstract

A binary acid accelerated oxidative radical annulation of sulfonyl hydrazones with simple olefins provides six-membered heterocycles. The method offers a rapid and efficient approach to tetrahydropyridazines which are key structural motifs in pharmaceutically active compounds.

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Key Words

N-heterocyles, TBHP, binary-acid, oxidative radical annulation

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ID: J54-Y2016