Synthesis of Quaternary 3,3-Disubstituted 2-Oxindoles from 2-Substituted Indole Using Selectfluor

Xiaojian Jiang*, Junjie Yang, Feng Zhang, Pei Yu, Peng Yi, Yewei Sun* and Yuqiang Wang

*Institute of New Drug Research, College of Pharmacy, Jinan University, Guangzhou 510632, China, Email: chemjxj2015jnu.edu.cn, yxy0723163.com

X. Jiang, J. Yang, F. Zhang, P. Yu, P. Yi, Y. Sun, Y. Wang, Org. Lett., 2016, 18, 3154-3157.

DOI: 10.1021/acs.orglett.6b01367

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Abstract

A facile method enables the construction of quaternary 3,3-disubstituted 2-oxindoles from 2-substituted indoles without a catalyst under mild conditions via an iminium-intermediate-triggered 1,2-rearrangement.

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Key Words

Oxindoles, Selectfluor

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ID: J54-Y2016