Catalytic Asymmetric [4 + 1] Annulation of Sulfur Ylides with Copper-Allenylidene Intermediates
Qiang Wang, Tian-Ren Li, Liang-Qiu Lu*, Miao-Miao Li, Kai Zhang and Wen-Jing Xiao*
*College of Chemistry, Central China Normal University, 152
Luoyu Road, Wuhan, Hubei 430079, China, Email:
luliangqiu
mail.ccnu.edu.cn, wxiaomail.ccnu.edu.cn
Q. Wang, T.-R. Li, L.-Q. Lu, M.-M. Li, K. Zhang, W.-J. Xiao, J. Am. Chem. Soc., 2016, 138, 8360-8363.
DOI: 10.1021/jacs.6b04414
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Abstract
A copper-catalyzed asymmetric decarboxylative [4 + 1] cycloaddition of propargylic carbamates and sulfur ylides provides chiral indolines with synthetically flexible alkyne groups in good yields and with high enantio- and diastereoselectivities.
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Key Words
ID: J48-Y2016
