Asymmetric Hydroarylation of Vinylarenes Using a Synergistic Combination of CuH and Pd Catalysis
Stig D. Friis, Michael T. Pirnot and Stephen L. Buchwald*
*Department of Chemistry, Massachusetts Institute of
Technology, Cambridge, Massachusetts 02139, United States, Email: sbuchwal
mit.edu
S. D. Friis, M. T. Pirnot, S. L. Buchwald, J. Am. Chem. Soc., 2016, 138, 8372-8375.
DOI: 10.1021/jacs.6b04566
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Abstract
Judicious choice of ligand for both copper(I) hydride and palladium catalysis enabled a hydroarylation protocol to work for an extensive array of aryl bromides and styrenes, including β-substituted vinylarenes and six-membered heterocycles, under relatively mild conditions.
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Key Words
diarylmethane derivatives, copper hydride, silanes
ID: J48-Y2016
