Asymmetric Hydroarylation of Vinylarenes Using a Synergistic Combination of CuH and Pd Catalysis
Stig D. Friis, Michael T. Pirnot and Stephen L. Buchwald*
*Department of Chemistry, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, United States, Email: sbuchwalmit.edu
S. D. Friis, M. T. Pirnot, S. L. Buchwald, J. Am. Chem. Soc., 2016, 138, 8372-8375.
DOI: 10.1021/jacs.6b04566 (free Supporting Information)
see article for more reactions
Judicious choice of ligand for both copper(I) hydride and palladium catalysis enabled a hydroarylation protocol to work for an extensive array of aryl bromides and styrenes, including β-substituted vinylarenes and six-membered heterocycles, under relatively mild conditions.
see article for more examples