Metal-Free Amidation of Acids with Formamides and T3P®
Linda Bannwart, Stefan Abele, Simone Tortoioli*
*Chemistry Process R&D, Actelion Pharmaceuticals Ltd.,
Gewerbestrasse 16, 4123 Allschwil, Switzerland, Email: simone.tortoioli
actelion.com
L. Bannwart, S. Abele, S. Tortoioli, Synthesis, 2016, 48, 2069-2078.
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Abstract
A simple and metal-free method for the direct formation of dialkylamides from carboxylic acids employs N,N-dialkylformamides as amine source. The one-pot reaction is promoted by propylphosphonic anhydride (T3P®) in the presence of 0.5 equivalents of HCl.
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Key Words
formamides, propylphosphonic anhydride, amidation, carboxylic acids, metal-free
ID: J66-Y2016
