Synthesis of S-Aryl Phosphorothioates by Copper-Catalyzed Phosphorothiolation of Diaryliodonium and Arenediazonium Salts
Liangliang Zhang, Pengbo Zhang, Xueqin Li, Jian Xu*, Guo Tang* and Yufen Zhao
*College of Chemistry and Chemical Engineering, Xiamen University, Xiamen 361005; College of Chemical Engineering, Huaqiao University, Xiamen 361021, China, Email: xujian2024qq.com, t12g21xmu.edu.cn
L. Zhang, P. Zhang, X. Li, J. Xu, G. Tang, Y. Zhao, J. Org. Chem., 2016, 81, 5566-5573.
DOI: 10.1021/acs.joc.6b00925 (free Supporting Information)
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Green methods based on copper-catalyzed multicomponent reactions enable the synthesis of S-aryl phosphorothioates from diaryliodonium/arenediazonium salts, elemental sulfur, and R2P(O)H compounds in very good yields at room temperature. These transformations allow the direct formation of P-S and C-S bonds in one reaction.
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J. Xu, L. Zhang, X. Li, Y. Gao, G. Tang, Y. Zhao, Org. Lett., 2016, 18, 1100-1103.