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Gold-Catalyzed Intermolecular Ynamide Amination-Initiated Aza-Nazarov Cyclization: Access to Functionalized 2-Aminopyrroles

Chao Shu, Yong-Heng Wang, Cang-Hai Shen, Peng-Peng Ruan, Xin Lu* and Long-Wu Ye*

*College of Chemistry and Chemical Engineering, Xiamen University, Xiamen 361005, China, Email:,

C. Shu, Y.-H. Wang, C.-H. Shen, P.-P. Ruan, X. Lu, L-W. Ye, Org. Lett., 2016, 18, 3254-3257.

DOI: 10.1021/acs.orglett.6b01503

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A gold-catalyzed intermolecular ynamide amination-initiated aza-Nazarov cyclization enables a facile and efficient synthesis of various 2-aminopyrroles in good yields. High flexibility, broad substrate scope, and mild nature of this reaction render it a viable alternative for the construction of 2-aminopyrroles.

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Key Words

pyrroles, Nazarov cyclization

ID: J54-Y2016