A Mild Strategy for the Preparation of Phenols via the Ligand-Free Copper-Catalyzed O-Arylation of para-Toluenesulfonic Acid
Bryan Yong-Hao Tan, Yong-Chua Teo*
*Natural Sciences and Science Education, National Institute
of Education, Nanyang Technological University, Nanyang Walk, Singapore 637616,
Singapore, Email: yongchua.teo
nie.edu.sg
B. Y.-H. Tan, Y.-C. Teo, Synlett, 2016, 27, 1814-1819.
DOI: 10.1055/s-0035-1561623
Abstract
A facile, simple, and mild ligand-free copper-catalyzed reaction provides substituted phenols in good yields from aryl iodides via an O-arylsulfonate intermediate that is hydrolyzed. This protocol offers a wide substrate scope and functional group tolerance.
see article for more examples
Key Words
phenols, copper, ligand-free, water, p-toluenesulfonic acid
ID: J60-Y2016
