Ligand-Controlled Cobalt-Catalyzed Transfer Hydrogenation of Alkynes: Stereodivergent Synthesis of Z- and E-Alkenes
Shaomin Fu, Nan-Yu Chen, Xufang Liu, Zhihui Shao, Shu-Ping Luo* and Qiang Liu*
*Zhejiang University of Technology, Hangzhou 310014; Department of Chemistry, Tsinghua University, Beijing 100084, China, Email: luoshupingzjut.edu.cn, qiang_liumail.tsinghua.edu.cn
S. Fu, N.-Y. Chen, X. Liu, Z. Shao, S.-P. Luo, Q. Liu, J. Am. Chem. Soc., 2016, 138, 8588-8594.
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A cobalt-catalyzed stereodivergent transfer hydrogenation of alkynes provides either Z- or E-alkenes based on a rational catalyst design. Substrates bearing a wide range of functional groups can be hydrogenated in good yields using catalyst loadings as low as 0.2 mol %.
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semireduction of alkynes, ammonia borane