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Ligand-Controlled Cobalt-Catalyzed Transfer Hydrogenation of Alkynes: Stereodivergent Synthesis of Z- and E-Alkenes

Shaomin Fu, Nan-Yu Chen, Xufang Liu, Zhihui Shao, Shu-Ping Luo* and Qiang Liu*

*Zhejiang University of Technology, Hangzhou 310014; Department of Chemistry, Tsinghua University, Beijing 100084, China, Email:,

S. Fu, N.-Y. Chen, X. Liu, Z. Shao, S.-P. Luo, Q. Liu, J. Am. Chem. Soc., 2016, 138, 8588-8594.

DOI: 10.1021/jacs.6b04271

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A cobalt-catalyzed stereodivergent transfer hydrogenation of alkynes provides either Z- or E-alkenes based on a rational catalyst design. Substrates bearing a wide range of functional groups can be hydrogenated in good yields using catalyst loadings as low as 0.2 mol %.

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Key Words

semireduction of alkynes, ammonia borane

ID: J48-Y2016