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Synthesis of 2-Sulfenylindenones via One-Pot Tandem Meyer-Schuster Rearrangement and Radical Cyclization of Arylpropynols with Disulfides

Xing-Song Zhang, Jun-Ying Jiao, Xiao-Hong Zhang*, Bo-Lun Hu and Xing-Guo Zhang*

*College of Chemistry and Materials Engineering, Wenzhou University, Wenzhou 325035, China, Email:,

X.-S. Zhang, J.-Y. Jiao, X.-H. Zhang, B.-L. Hu, X.-G. Zhang, J. Org. Chem., 2016, 81, 5710-5716.

DOI: 10.1021/acs.joc.6b00762

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One-pot tandem Meyer-Schuster rearrangement of arylpropynols and successive radical cyclization with disulfides enables the synthesis of 2-sulfenylindenone derivatives in good yields. The reaction tolerates a number of functional groups.

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Key Words

Indenones, Potassium Peroxydisulfate, Iodine

ID: J42-Y2016