Base-Promoted Cascade Approach for the Preparation of Reduced Knoevenagel Adducts Using Hantzsch Esters as Reducing Agent in Water
Tao He, Ronghua Shi, Yimou Gong, Guangyou Jiang, Ming Liu, Shan Qian, Zhouyu Wang*
*Department of Chemistry, Xihua University, Chengdu, 610039,
P. R. of China, Email: zhouyuwang77
gmail.com
T. He, R. Shi, Y. Gong, G. Jiang, M. Liu, S. Qian, Z. Wang, Synlett, 2016, 27, 1864-1869.
DOI: 10.1055/s-0035-1562099
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Abstract
Hantzsch ester as reducing agent enables a cascade Knoevenagel condensation-reduction approach in water. Various reduced Knoevenagel adducts could be easily prepared by direct alkylation of malononitrile, ethyl 2-cyanoacetate, and 2-(4-nitrophenyl)acetonitrile, respectively.
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Key Words
cascade reaction, Knoevenagel condensation, reduction, Hantzsch ester, benzylation
ID: J60-Y2016
