Organic Chemistry Portal



Palladium-Catalyzed Intermolecular Aerobic Annulation of o-Alkenylanilines and Alkynes for Quinoline Synthesis

Jia Zheng, Zun Li, Liangbin Huang, Wanqing Wu*, Jianxiao Li and Huanfeng Jiang*

*School of Chemistry and Chemical Engineering, South China University of Technology, Guangzhou 510640, P. R. China, Email:,

J. Zheng, T. Li, L. Huang, W. Wu, J. Li, H. Jiang, Org. Lett., 2016, 18, 3514-3517.

DOI: 10.1021/acs.orglett.6b01008

see article for more reactions


A Pd-catalyzed oxidative cyclization of o-vinylanilines and alkynes in the presence of molecular oxygen enables the construction of 2,3-disubstituted quinolines via intermolecular amination of alkyne, insertion of the olefin, and oxidative cleavage of a C-C bond.

see article for more examples

Key Words

quinolines, oxygen

ID: J54-Y2016