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Hexafluoro-2-propanol-Promoted Intermolecular Friedel-Crafts Acylation Reaction

Rakesh H. Vekariya and Jeffrey Aubé*

*Division of Chemical Biology and Medicinal Chemistry, 125 Mason Farm Road, CB 7363, University of North Carolina, Chapel Hill, North Carolina 27599-7363, United States, Email:

R. H. Vekariya, J. Aubé, Org. Lett., 2016, 18, 3534-3537.

DOI: 10.1021/acs.orglett.6b01460

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An intermolecular Friedel-Crafts acylation in hexafluoro-2-propanol provides aryl and heteroaryl ketones at room temperature without any additional reagents.

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Key Words

Friedel-Crafts acylation

ID: J54-Y2016