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Copper(II)-Mediated Aerobic Oxidation of Benzylimidates: Synthesis of Primary α-Ketoamides

Yogesh Kumar, Mukta Shaw, Rima Thakur and Amit Kumar*

*Department of Chemistry, Indian Institute of Technology Patna, Bihta 801103, Bihar, India, Email:

Y. Kumar, M. Shaw, R. Thakur, A. Kumar, J. Org. Chem., 2016, 81, 6617-6625.

DOI: 10.1021/acs.joc.6b01262

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Benzylimidates can directly be converted to primary α-ketoamides by using molecular oxygen as an oxidant in the presence of copper(II) salt. The reaction offers a wide substrate scope and operationally mild conditions.

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Key Words

α-keto amides, oxygen

ID: J42-Y2016