Copper(II)-Mediated Aerobic Oxidation of Benzylimidates: Synthesis of Primary α-Ketoamides
Yogesh Kumar, Mukta Shaw, Rima Thakur and Amit Kumar*
*Department of Chemistry, Indian Institute of Technology Patna, Bihta 801103, Bihar, India, Email: amitktiitp.ac.in
Y. Kumar, M. Shaw, R. Thakur, A. Kumar, J. Org. Chem., 2016, 81, 6617-6625.
DOI: 10.1021/acs.joc.6b01262 (free Supporting Information)
see article for more reactions
Benzylimidates can directly be converted to primary α-ketoamides by using molecular oxygen as an oxidant in the presence of copper(II) salt. The reaction offers a wide substrate scope and operationally mild conditions.
see article for more examples