Synthesis of α-Fluoroketones from Vinyl Azides and Mechanism Interrogation
Shu-Wei Wu and Feng Liu*
*Department of Medicinal Chemistry, College of Pharmaceutical
Sciences, Soochow University, 199 Ren-Ai Road, Suzhou, Jiangsu 215123, People's
Republic of China, Email: fliu2
suda.edu.cn
S.-W. Wu, F. Liu, Org. Lett., 2016, 18, 3642-3645.
DOI: 10.1021/acs.orglett.6b01691
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Abstract
An efficient and mild fluorination of vinyl azides enables the synthesis of α-fluoroketones via a single-electron transfer (SET) and a subsequent fluorine atom transfer.
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Key Words
α-fluoroketones, hydrolysis, Selectfluor
ID: J54-Y2016
