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Synthesis of α-Fluoroketones from Vinyl Azides and Mechanism Interrogation

Shu-Wei Wu and Feng Liu*

*Department of Medicinal Chemistry, College of Pharmaceutical Sciences, Soochow University, 199 Ren-Ai Road, Suzhou, Jiangsu 215123, People's Republic of China, Email: fliu2suda.edu.cn

S.-W. Wu, F. Liu, Org. Lett., 2016, 18, 3642-3645.

DOI: 10.1021/acs.orglett.6b01691 (free Supporting Information)


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Abstract

An efficient and mild fluorination of vinyl azides enables the synthesis of α-fluoroketones via a single-electron transfer (SET) and a subsequent fluorine atom transfer.

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Key Words

α-fluoroketones, hydrolysis, Selectfluor


ID: J54-Y2016