Palladium-Catalyzed Nitration of Meyer-Schuster Intermediates with tBuONO as Nitrogen Source at Ambient Temperature
Yuanguang Lin, Weiguang Kong and Qiuling Song*
*College of Chemical Engineering and College of Material Sciences Engineering at Huaqiao University, 668 Jimei Boulevard, Xiamen, Fujian 361021, P. R. China, Email: qsonghqu.edu.cn
Y. Lin, W. Kong, Q. Song, Org. Lett., 2016, 18, 3702-3705.
DOI: 10.1021/acs.orglett.6b01740 (free Supporting Information)
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A domino palladium-catalyzed nitration of Meyer-Schuster intermediates, which were generated in situ from propargylic alcohols, with t-BuONO provides α-nitro enones in very good yields at room temperature with a broad functional group tolerance.
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