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Ruthenium(II)-Catalyzed Hydration of Terminal Alkynes in PEG-400

Prathama S. Mainkar, Venkataraju Chippala, Rambabu Chegondi, Srivari Chandrasekhar*

*Division of Natural Products Chemistry, CSIR - Indian Institute of Chemical Technology, Hyderabad, 500007, India, Email:

P. S. Mainkar, V. Chippala, R. Chegondi, S. Chandrasekhar, Synlett, 2016, 27, 1969-1972.

DOI: 10.1055/s-0035-1561864 (free Supporting Information)


A mild ruthenium(II)-catalyzed hydration of terminal alkynes in PEG-400 provides methyl ketones in high yield through Markovnikov addition of water.

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Key Words

PEG-400, ruthenium, methyl ketones, terminal alkynes, hydration

ID: J60-Y2016