Organic Chemistry Portal



Co(III)-Catalyzed, Internal and Terminal Alkyne-Compatible Synthesis of Indoles

Shuguang Zhou, Jinhu Wang, Lili Wang, Kehao Chen, Chao Song and Jin Zhu*

*Department of Polymer Science and Engineering, School of Chemistry and Chemical Engineering, Nanjing University, Nanjing 210093, China, Email:

S. Zhou, J. Wang, L. Wang, K. Chen, C. Song, J. Zhu, Org. Lett., 2016, 18, 3806-3809.

DOI: 10.1021/acs.orglett.6b01805

see article for more reactions


A Co(III)-catalyzed reaction provides indoles from arylhydrazines and alkynes. Notable synthetic features include regioselectivity for a meta-substituted arylhydrazine, regioselectivity for a chain-branched terminal alkyne, formal incorporation of an acetylenic unit through C2-desilylation and formal inversion of regioselectivity through consecutive C3-derivatization and C2-desilylation processes.

see article for more examples

Key Words


ID: J54-Y2016