Organic Chemistry Portal



One-Pot Amide Bond Formation from Aldehydes and Amines via a Photoorganocatalytic Activation of Aldehydes

Giorgos N. Papadopoulos and Christoforos G. Kokotos*

*Laboratory of Organic Chemistry, Department of Chemistry, National and Kapodestrian University of Athens, Panepistimiopolis 15771, Athens, Greece, Email:

G. N. Papadopoulos, C. G. Kokotos, J. Org. Chem., 2016, 81, 7023-7028.

DOI: 10.1021/acs.joc.6b00488

see article for more reactions


A photoorganocatalytic reaction of aldehydes with diisopropyl azodicarboxylate leads to an intermediate carbonyl imide, which can react with a variety of amines to afford amides. This method enables a mild, one-pot, and environmentally friendly synthesis of amides from aldehydes and amines.

see article for more examples

Key Words

oxidative amidation, DIAD

ID: J42-Y2016