One-Pot Amide Bond Formation from Aldehydes and Amines via a Photoorganocatalytic Activation of Aldehydes
Giorgos N. Papadopoulos and Christoforos G. Kokotos*
*Laboratory of Organic Chemistry, Department of Chemistry, National and Kapodestrian University of Athens, Panepistimiopolis 15771, Athens, Greece, Email: ckokotoschem.uoa.gr
G. N. Papadopoulos, C. G. Kokotos, J. Org. Chem., 2016, 81, 7023-7028.
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A photoorganocatalytic reaction of aldehydes with diisopropyl azodicarboxylate leads to an intermediate carbonyl imide, which can react with a variety of amines to afford amides. This method enables a mild, one-pot, and environmentally friendly synthesis of amides from aldehydes and amines.
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