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Aerobic Oxidative Carbonylation of Enamides by Merging Palladium with Photoredox Catalysis

Kun Liu, Minzhu Zou and Aiwen Lei*

*College of Chemistry and Molecular Sciences, the Institute for Advanced Studies (IAS), Wuhan University, Wuhan 430072, China, Email:

K. Liu, M. Zou, A. Lei, J. Org. Chem., 2016, 81, 7088-7092.

DOI: 10.1021/acs.joc.6b00965

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The combination of palladium and photoredox catalysis enables an aerobic intramolecular oxidative carbonylation of enamides. The dual catalytic system provides a mild and environmentally friendly method for the synthesis of 1,3-oxazin-6-ones without the use of a stoichiometric amount of hypervalent metal salts.

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Key Words

N-heterocycles, O-heterocycles, oxygen

ID: J42-Y2016