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The Synthesis of Multisubstituted Pyrroles via a Copper-Catalyzed Tandem Three-Component Reaction

Xue-Qing Mou, Zheng-Liang Xu, Li Xu, Shao-Hua Wang*, Bang-Hong Zhang, Di Zhang, Jie Wang, Wei-Ting Liu and Wen Bao

*School of Pharmacy and State Key Laboratory of Applied Organic Chemistry, Lanzhou University, Lanzhou 730000, P. R. China, Email:

X.-Q. Mou, Z.-L. Xu, L. Xu, S.-H. Wang, B.-H. Zhang, D. Zhang, J. Wang, W.-T. Liu, W. Bao, Org. Lett., 2016, 18, 4032-4035.

DOI: 10.1021/acs.orglett.6b01883

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An unprecedented nucleophilic addition/cyclization/aromatization cascade of simple starting materials, i.e., aromatic alkenes/alkynes, trimethylsilyl cyanide and N,N-disubstituted formamide provides multisubstituted pyrroles in good yields with high regioselectivities.

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Key Words

pyrroles, multicomponent reactions

ID: J54-Y2016