Method for Direct Synthesis of α-Cyanomethyl-β-dicarbonyl Compounds with Acetonitrile and 1,3-Dicarbonyls

Chenyang Wang, Yabo Li, Ming Gong, Qi Wu, Jianye Zhang, Jung Keun Kim*, Mengmeng Huang and Yangjie Wu*

*College of Chemistry and Molecular Engineering, Zhengzhou University, Zhengzhou 450052, P.R. China, Email: kimzzu.edu.cn, wyjzzu.edu.cn

C. Wang, Y. Li, M. Gong, Q. Wu, J. Zhang, J. K. Kim, M. Huang, Y. Wu, Org. Lett., 2016, 18, 4151-4153.

DOI: 10.1021/acs.orglett.6b01871

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Abstract

An efficient method enables the synthesis of α-cyanomethyl-β-dicarbonyls in good yields from MeCN and simple 1,3-dicarbonyls. A radical mechanism is proposed.

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Key Words

active methylenes, nitriles, DTBP

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ID: J54-Y2016