Organic Chemistry Portal



Zn(OTf)2-Mediated Expeditious and Solvent-Free Synthesis of Propargylamines via C-H Activation of Phenylacetylene

Prashant B. Sarode, Sandeep P. Bahekar, Hemant S. Chandak*

*Department of Chemistry, G. S. Science, Arts and Commerce College, Khamgaon 444303, India, Email:

P. B. Sarode, S. P. Bahekar, H. S. Chandak, Synlett, 2016, 27, 2209-2212.

DOI: 10.1055/s-0035-1562114 (free Supporting Information)

see article for more reactions


A Zn(OTf)2-mediated solvent-free synthesis of propargylamines proceeds effectively via A3 coupling of aldehydes, amines, and phenylacetylene. The protocol tolerates a broad range of substituted benzaldehydes, enolizable aldehydes, and formaldehyde. Recyclability of the catalyst, low catalyst loading, and use of inexpensive catalyst are the key features.

see article for more examples

Key Words

Zn(OTf)2, solvent-free synthesis, multicomponent reactions, propargylamines, green chemistry, C-H activation, A3 coupling, propargylamine

ID: J60-Y2016