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Reductive Cyclization of 1,6- and 1,7-Enynes Catalyzed by Iron Complexes

Tuo Xi, Xu Chen, Heyi Zhang, Zhan Lu*

*Department of Chemistry, Zhejiang University, Hangzhou 310027, P. R. of China, Email:

T. Xi, X. Chen, H. Zhang, Z. Lu, Synthesis, 2016, 48, 2837-2844.

DOI: 10.1055/s-0035-1561957 (free Supporting Information)

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An iron catalyst enables a reductive cyclization of 1,6- and 1,7-enynes. Alcohol, ketone, ester, ether, halide, amine, amide, imine, nitrile, silyl, and alkyne groups are tolerated under the mild reaction conditions. An enantioselective transformation was also conducted.

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Key Words

iron, catalysis, enynes, cyclizations, pyrrolidines

ID: J66-Y2016