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Transition-Metal-Free Cross-Coupling of Indium Organometallics with Chromene and Isochroman Acetals Mediated by BF3·OEt2

José M. Gil-Negrete, José Pérez Sestelo* and Luis A. Sarandeses*

*Centro de Investigaciones Científicas Avanzadas (CICA) and Departamento de Química Fundamental, Universidade da Coruña, E-15071 A Coruña, Spain, Email:,

J. M. Gil-Negrete, J. P. Sestelo, L. A. Sarandeses, Org. Lett., 2016, 18, 4316-4319.

DOI: 10.1021/acs.orglett.6b02058 (free Supporting Information)

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A transition-metal-free coupling of various triorganoindium reagents with chromene and isochroman acetals in the presence of BF3·OEt2 afforded 2-substituted chromenes and 1-substituted isochromans, respectively, in good yields. The reactions proceed with only 50 mol % of the organometallic, thus demonstrating the efficiency of these species.

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Key Words

chromenes, isochromans

ID: J54-Y2016