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Preparation of Optically Active cis-Cyclopropane Carboxylates: Cyclopropanation of α-Silyl Stryenes with Aryldiazoacetates and Desilylation of the Resulting Silyl Cyclopropanes

Yan Su, Qing-Fang Li, Yu-Ming Zhao and Peiming Gu*

*School of Chemistry & Chemical Engineering, Key Laboratory of Energy Sources & Engineering, and Ningxia Engineering and Research Center for Natural Medicines, Ningxia University, Yinchuan 750021, China, Email:

Y. Su, Q.-F. Li, Y.-M. Zhao, P. Gu, Org. Lett., 2016, 18, 4356-4359.

DOI: 10.1021/acs.orglett.6b02117


Optically active cis-cyclopropane carboxylates can be prepared via a Rh2(S-PTAD)4-catalyzed cyclopropanation of α-silyl styrenes with aryl diazoacetates followed by desilylation of the resulting silyl cyclopropane carboxylates.

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Key Words

cyclopropanes, desilylation

ID: J54-Y2016