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Cyanation of Phenol Derivatives with Aminoacetonitriles by Nickel Catalysis

Ryosuke Takise, Kenichiro Itami* and Junichiro Yamaguchi*

*Graduate School of Science, Nagoya University, Chikusa, Nagoya 464-8602; Department of Applied Chemistry, Waseda University, 3-4-1 Ohkubo, Shinjuku, Tokyo 169-8555, Japan, Email: itamichem.nagoya-u.ac.jp, junyamaguchiwaseda.jp

R. Takise, K. Itami, J. Yamaguchi, Org. Lett., 2016, 18, 4428-4431.

DOI: 10.1021/acs.orglett.6b02265 (free Supporting Information)


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Abstract

A nickel-based catalytic system consisting of a unique diphosphine ligand such as dcype or dcypt enables the cyanation of versatile phenol derivatives such as aryl carbamates and aryl pivalates with aminoacetonitriles as metal-free cyanating agents This method is environmentally benign and easy-to-use.

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Key Words

cyanation


ID: J54-Y2016