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Access to the Cinnoline Scaffold via Rhodium-Catalyzed Intermolecular Cyclization under Mild Conditions

Chao Song, Chen Yang, Feifei Zhang, Jinhu Wang and Jin Zhu*

*School of Chemistry and Chemical Engineering, Collaborative Innovation Center of Chemistry for Life Sciences, Nanjing University, Nanjing 210093, China, Email:

C. Song, C. Yang, F. Zhang, J. Wang, J. Zhu, Org. Lett., 2016, 18, 4510-4513.

DOI: 10.1021/acs.orglett.6b02103

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A Rh(III)-catalyzed, N-amino (hydrazine)-directed C-H functionalization with α-diazo-β-ketoesters provides a simple and efficient access to the cinnoline scaffold via successive C-H activation/C-C coupling/intramolecular dehydration.

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Key Words

benzofused N-heterocycles

ID: J54-Y2016