Phosphorus(III)-Mediated Stereoconvergent Formal [4+1]-Cycloannulation of 1,2-Dicarbonyls and o-Quinone Methides: A Multicomponent Assembly of 2,3-Dihydrobenzofurans
Kevin X. Rodriguez, Justin D. Vail and Brandon L. Ashfeld*
*Department of Chemistry and Biochemistry, University of
Notre Dame, Notre Dame, Indiana 46556, United States, Email: bashfeld
nd.edu
K. X. Rodriguez, J. D. Vail, B. L. Ashfeld, Org. Lett., 2016, 18, 4514-4517.
DOI: 10.1021/acs.orglett.6b02122
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Abstract
A phosphorus(III)-mediated formal [4+1]-cycloaddition of 1,2-dicarbonyls and o-quinone methides provides 2,3-dihydrobenzofurans. Subtle steric interactions involved in the [4+1]-cycloannulation have an impact on yield and stereoselectivity in dihydrobenzofuran formation.
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Key Words
ID: J54-Y2016
