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Synthesis of Substituted 3(2H)-Furanones Using Alkylative Intramolecular Cyclization of Sulfonium Salts

Sho Inagaki, Mika Ukaku, Akira Chiba, Fumi Takahashi, Yasuharu Yoshimi, Toshio Morita and Tomikazu Kawano*

*Department of Medicinal and Organic Chemistry, School of Pharmacy, Iwate Medical University, Yahaba, Iwate 028-3694, Japan, Email:

S. Inagaki, M. Ukaku, A. Chiba, F. Takahashi, Y. Yoshimi, T. Morita, T. Kawano, J. Org. Chem., 2016, 81, 8363-8369.

DOI: 10.1021/acs.joc.6b01528

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A facile alkylative intramolecular cyclization of 3-alkoxycarbonyl-2-oxopropyldiphenylsulfonium salts provides 4-alkylated 3(2H)-furanones in good yields under mild conditions.

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Key Words


ID: J42-Y2016