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Iminophenyl Oxazolinylphenylamine for Enantioselective Cobalt-Catalyzed Hydrosilylation of Aryl Ketones

Xu Chen and Zhan Lu*

*Department of Chemistry, Zhejiang University, Hangzhou 310058, China, Email: luzhanzju.edu.cn

X. Chen, Z. Lu, Org. Lett., 2016, 18, 4658-4661.

DOI: 10.1021/acs.orglett.6b02260 (free Supporting Information)


Abstract

A family of chiral iminophenyl oxazolinylphenylamines (IPOPA) ligands enables an efficient cobalt-catalyzed asymmetric hydrosilylation of simple ketones with a low catalyst loading of CoCl2 to afford chiral alcohols in good yields with high enantioselectivities.

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Key Words

reduction of carbonyl compounds, silanes


ID: J54-Y2016