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Metal-Free, DTBP-Mediated Methylthiolation of Arylboronic Acids with Dimethyldisulfide

Xiang-mei Wu*, Jia-ming Lou, Guo-bing Yan*

*Department of Chemistry, Lishui University, Lishui, Zhejiang 323000, P. R. of China, Email:,

X.-m. Wu, J.-m. Lou, G.-b. Yan, Synlett, 2016, 27, 2269-2273.

DOI: 10.1055/s-0035-1562499

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An efficient coupling of arylboronic acids with dimethyldisulfide under metal-free conditions provides aryl methyl sulfides. The method offers operational simplicity, satisfactory yields, excellent functional-group tolerance, as well as mild reaction conditions.

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Key Words

methylthiolation, sulfides, arylboronic acids, dimethyldisulfide, aryl methyl sulfides, di-tert-butyl peroxide

ID: J60-Y2016