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Copper-Catalyzed Three-Component Tandem Cyclization for One-Pot Synthesis of 1,4-Benzothiazines

Jing-Jing Chu, Bo-Lun Hu, Zhi-Yong Liao and Xing-Guo Zhang*

*College of Chemistry and Materials Engineering, Wenzhou University, Wenzhou 325035, China, Email:

J.-J. Chu, B.-L. Hu, Z.-Y. Liao, X.-G. Zhang, J. Org. Chem., 2016, 81, 8647-8652.

DOI: 10.1021/acs.joc.6b01668

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A copper-catalyzed three-component tandem reaction enables a convenient and practical synthesis of 1,4-benzothiazines from terminal alkynes, 2-iodophenyl isothiocyanates, and aqueous ammonia.

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Key Words

1,4-benzothiazines, benzo-fused N-heterocycles, benzo-fused S-heterocycles, multicomponent reactions

ID: J42-Y2016