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Regioselective Iodine-Catalyzed Construction of Polysubstituted Pyrroles from Allenes and Enamines

Yu Wang, Chen-Min Jiang, Hong-Liang Li, Fu-Sheng He, Xiaoyan Luo* and Wei-Ping Deng*

*School of Pharmacy and Shanghai Key Laboratory of New Drug Design, East China University of Science and Technology, 130 Meilong Road, Shanghai 200237, China, Email:,

Y. Wang, C.-M. Jiang, H.-L. Li, F.-S. He, X. Luo, W.-P. Deng, J. Org. Chem., 2016, 81, 8653-8658.

DOI: 10.1021/acs.joc.6b01737

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A iodine-catalyzed tandem Michael addition/oxidative annulation of allenes and enamines provides polysubstituted pyrroles in an efficient and highly regioselective way in good yields under mild conditions.

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Key Words

Pyrroles, TBHP

ID: J42-Y2016