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Regioselective Synthesis of 2,3,4-Trisubstituted Pyrroles via Pd(II)-Catalyzed Three-Component Cascade Reactions of Amines, Alkyne Esters, and Alkenes

Xu Zhang*, Xuefeng Xu, Gong Chen and Wei Yi*

*College of Chemistry and Pharmaceutical Engineering, Nanyang Normal University, Nanyang 473061; Chinese Academy of Sciences, Shanghai 201203, China, Email:,

X. Zhang, X. Xu, G. Chen, W. Yi, Org. Lett., 2016, 18, 4864-4867.

DOI: 10.1021/acs.orglett.6b02325


An efficient and versatile Pd(II)-catalyzed oxidative three-component cascade reaction of diverse amines, alkyne esters, and alkenes enables the direct synthesis of diverse 2,3,4-trisubstituted pyrroles with broad functional group tolerance and in good to excellent yields.

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Key Words

pyrroles, multicomponent reactions, potassium peroxydisulfate

ID: J54-Y2016