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Synthesis of Isothiazole via the Rhodium-Catalyzed Transannulation of 1,2,3-Thiadiazoles with Nitriles

Boram Seo, Ya Gob Kim and Phil Ho Lee*

*Department of Chemistry, Kangwon National University, Chuncheon 24341, Republic of Korea, Email: phleekangwon.ac.kr

B. Seo, Y. G. Kim, P. H. Lee, Org. Lett., 2016, 18, 5050-5053.

DOI: 10.1021/acs.orglett.6b02499 (free Supporting Information)


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Abstract

A Rh-catalyzed transannulation of 1,2,3-thiadiazoles with alkyl, aryl, and heteroaryl nitriles provides a wide variety of isothiazoles via an α-thiavinyl Rh-carbenoid intermediate.

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Key Words

Isothiazoles


ID: J54-Y2016