Synthesis of Isothiazole via the Rhodium-Catalyzed Transannulation of 1,2,3-Thiadiazoles with Nitriles
Boram Seo, Ya Gob Kim and Phil Ho Lee*
*Department of Chemistry, Kangwon National University,
Chuncheon 24341, Republic of Korea, Email: phlee
kangwon.ac.kr
B. Seo, Y. G. Kim, P. H. Lee, Org. Lett., 2016, 18, 5050-5053.
DOI: 10.1021/acs.orglett.6b02499
see article for more reactions
Abstract
A Rh-catalyzed transannulation of 1,2,3-thiadiazoles with alkyl, aryl, and heteroaryl nitriles provides a wide variety of isothiazoles via an α-thiavinyl Rh-carbenoid intermediate.
see article for more examples
Key Words
ID: J54-Y2016
