Combination of Enabling Technologies to Improve and Describe the Stereoselectivity of Wolff-Staudinger Cascade Reaction
B. Musio, F. Mariani, E. P. Śliwiński, M. A. Kabeshov, H. Odajima, S. V. Ley*
*University of Cambridge, Department of Chemistry, Lensfield
Road, Cambridge, CB2 1EW, UK, Email: svl1000
cam.ac.uk
B. Musio, F. Mariani, E. P. Śliwiński, M. A. Kabeshov, H. Odajima, S. V. Ley, Synthesis, 2016, 48, 3515-3526.
DOI: 10.1055/s-0035-1562579
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Abstract
A microwave-assisted flow generation of primary ketenes by thermal decomposition of α-diazoketones at high temperature followed by in situ reaction with amines and imines provides a number of amides and trans β-lactams, respectively, in very good yields.
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see article for more examples
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Key Words
microwave, Wolff rearrangement, Staudinger synthesis, flow chemistry, microwave synthesis, Augmented Reality, molecular visualisation
ID: J66-Y2016
