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Enantioselective Synthesis of Quaternary Stereocenters via Chromium Catalysis

Yang Xiong and Guozhu Zhang*

*State Key Laboratory of Organometallic Chemistry, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, 345 Lingling Road, Shanghai 200032, P. R. China, Email:

Y. Xiong, G. Zhang, Org. Lett., 2016, 18, 5094-5097.

DOI: 10.1021/acs.orglett.6b02540

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Asymmetric allylation of aldehydes with γ-disubstituted allyl halides in the presence of a sulfonamide/oxazoline chromium complex provides various synthetically useful α-homoallylic alcohols with two consecutive stereogenic centers, including one quaternary carbon, in a highly diastereoselective and enantioselective manner.

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Key Words

homoallylic alcohols

ID: J54-Y2016