Enantioselective Synthesis of Quaternary Stereocenters via Chromium Catalysis
Yang Xiong and Guozhu Zhang*
*State Key Laboratory of Organometallic Chemistry, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, 345 Lingling Road, Shanghai 200032, P. R. China, Email: guozhuzhangsioc.ac.cn
Y. Xiong, G. Zhang, Org. Lett., 2016, 18, 5094-5097.
DOI: 10.1021/acs.orglett.6b02540 (free Supporting Information)
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Asymmetric allylation of aldehydes with γ-disubstituted allyl halides in the presence of a sulfonamide/oxazoline chromium complex provides various synthetically useful α-homoallylic alcohols with two consecutive stereogenic centers, including one quaternary carbon, in a highly diastereoselective and enantioselective manner.
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