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Synthesis of Enantioenriched Pyrrolidines via Gold-Catalyzed Tandem Cycloisomerization/Hydrogenation of Chiral Homopropargyl Sulfonamides

Yong-Fei Yu, Chao Shu, Tong-De Tan, Long Li, Shahid Rafique and Long-Wu Ye*

*College of Chemistry and Chemical Engineering, Xiamen University, Xiamen 361005, China, Email:

Y.-F. Yu, C. Shu, T.-D. Tan, L. Li, S. Rafique, L.-W. Ye, Org. Lett., 2016, 18, 5178-5181.

DOI: 10.1021/acs.orglett.6b02736

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A novel gold-catalyzed tandem cycloisomerization/hydrogenation of chiral homopropargyl sulfonamides provides various enantioenriched pyrrolidines in excellent yields and excellent enantioselectivities.

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Key Words

pyrrolidines, silanes

ID: J54-Y2016