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A Combination System of p-Toluenesulfonic Acid and Acetic Acid for the Hydration of Alkynes

Haixuan Liu, Yunyang Wei, Chun Cai*

*School of Chemical Engineering, Nanjing University of Science and Technology, Xiaolingwei 200, Nanjing 210094, P. R. of China, Email: c.cainjust.edu.cn

H. Liu, Y. Wei, C. Cai, Synlett, 2016, 27, 2378-2383.

DOI: 10.1055/s-0035-1562779


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Abstract

A simple combination of p-toluenesulfonic acid and acetic acid enables an efficient hydration of alkynes. The reaction provides ketones in good to excellent yields under mild conditionsvia stepwise process (addition and then hydrolysis).

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Key Words

hydration, alkynes, ketones, hydrolysis, vinyl sulfonates


ID: J60-Y2016