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A Green Approach to the Synthesis of α-Amino Phosphonate in Water Medium: Carbene Insertion into the N-H Bond by Cu(I) Catalyst

Kankanala Ramakrishna, Jisha Mary Thomas and Chinnappan Sivasankar*

*Catalysis and Energy Laboratory (A Central University), Department of Chemistry Pondicherry University, Puducherry 605014, India, Email:

K. Ramakrishna, J. M. Thomas, C. Sivasankar, J. Org. Chem., 2016, 81, 9826-9835.

DOI: 10.1021/acs.joc.6b01940 (free Supporting Information)

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A synthesis of various amino phosphonates has been achieved via phosphonate substituted carbene insertion into the N-H bond of aniline catalyzed by readily available copper salt under mild reaction conditions in water. Using this environmentally benign methodology a large number of biologically important amino phosphonates have been synthesized in good isolated yields.

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Key Words

α-Amino Phosphonates, Amination

ID: J42-Y2016